Abstracts
Use of Caffeic Acid Phenethyl Ester (CAPE), a Novel Inhibitor of the Nuclear Factor Kappa B (NF-kB) Pathway, in Experimental Chemotherapy of Human Ovarian Carcinoma Cell Line (SKOV-3).
A novel inhibitor of the NF-KB pathway, caffeic acid phenethyl ester (CAPE), was found to induce apoptosis in microscopic tumors derived from a metastatic ovarian carcinoma cell line (SKOV-3) and showed enhanced effects in combined chemotherapy with aspirin metabolite sodium salicylate. In addition, this research study investigated the combined chemotherapeutic action of CAPE and Taxol, and sodium salicylate and Taxol, and their effectiveness in the inhibition of tumor growth in vitro.
Enhanced Cytotoxicity of the Chemotherapeutic Drug Taxol When Used in Combination Therapy With Anti-Inflamatory Drug Sodium Salicylate on Human Ovarian Multicellular Spheroids of the SKOV-3 Cell Line